Saturday, May 1, 2010

Cushing Ulcers and Curling Ulcers

These are peptic ulcers caused by CNS injury and burns respectively.

One possible explanation for the development of Cushing ulcers is the stimulation of vagal nuclei due to the increased intracranial pressure which leads to increased secretion of gastric acid.

Curling ulcers may be explained by a reduced plasma volume, which leads to sloughing of the gastric mucosa or secretion of burn toxins (necrotic and carbonaceous materials released from burned cells) by the stomach.

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